Anti-CD11a [hu1124 (Efalizumab)]

Absolute Antibody

Anti-CD11a [hu1124 (Efalizumab)]

7

Binds to human LFA-1.

Efalizumab binds to the LFA-1 alpha I domain blocking the ICAM-1 binding site via steric hindrance.

Flow Cytometry, Neutralisation/Blocking

Block; FC

Research Use Only

Monoclonal

hu1124 (Efalizumab)

ITGAL

integrin subunit alpha L

antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide; CD11 antigen-like family member A; CD11A; integrin alpha-L; integrin gene promoter; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; LFA-1; LFA-1 alpha; LFA1A; LFA-1A; lymphocyte function-associated antigen 1, alpha polypeptide

Mouse

IgG2a

Integrin alpha-L

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

Efalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes.

-20°C,2°C to 8°C

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