Anti-CD11a/CD18 [YKIX490.6.4]

Absolute Antibody

Anti-CD11a/CD18 [YKIX490.6.4]

7

This antibody recognizes canine LFA-1, an integrin consisting of a 180kDa CD11a chain complexed with a 95kDa common beta chain, CD18. LFA-1 is expressed on T cells, B cells, macrophages and neutrophils.

This antibody binds CD11a/18, and has been shown to block T cell proliferation, cytotoxic T lymphocyte (CTL) lysis, antibody dependent cell mediated cytotoxic (ADCC) lysis and homotypic cell adhesion (Cobbold, 1994). This antibody has been used in IF and IP analysis to identify and characterise the canine homologue of human CD11a/18.

Flow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking

Blocking; IHC-fr; IHC-paraffin; IHC-resin; FC; IP

Research Use Only

Monoclonal

YKIX490.6.4

Canine

IgG2

This chimeric dog antibody was made using the variable domain sequences of the original Rat IgG2c format, for improved compatibility with existing reagents, assays and techniques.

Canine

Dog

This antibody was prepared by immunizing rats with canine thymocytes

-20°C,2°C to 8°C

12352203