anti-CD130 / gp130 antibody [B-K5] (azide free)
ARG23322
ApplicationsFunctional Assay, Flow Cytometry
Product group Antibodies
ReactivityHuman
TargetIL6ST
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-CD130 / gp130 antibody [B-K5] (azide free)
- Delivery Days Customer23
- ApplicationsFunctional Assay, Flow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDB-K5
- ConjugateUnconjugated
- Gene ID3572
- Target nameIL6ST
- Target descriptioninterleukin 6 cytokine family signal transducer
- Target synonymsCD130; CD130 antigen; CDW130; GP130; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130, oncostatin M receptor; HIES4; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6RB; interleukin receptor beta chain; interleukin-6 receptor subunit beta; interleukin-6 signal transducer; membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin-M receptor subunit alpha; sGP130
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203