anti-CD148 / DEP1 antibody [MEM-CD148 / 05] (Biotin)

Arigo Biolaboratories

anti-CD148 / DEP1 antibody [MEM-CD148 / 05] (Biotin)

23

Flow Cytometry

Research Use Only

Monoclonal

MEM-CD148/05

1 mg/ml

Biotin

PTPRJ

protein tyrosine phosphatase receptor type J

CD148; CD148 antigen; density-enhanced phosphatase 1; DEP1; DEP-1; HPTP eta; HPTPeta; human density enhanced phosphatase-1; protein tyrosine phosphatase, receptor type, J polypeptide; protein-tyrosine phosphatase eta; receptor-type tyrosine-protein phosphatase eta; R-PTP-ETA; R-PTP-J; SCC1; susceptibility to colon cancer 1, mouse, homolog of

Mouse

IgG2b

CD148 (also known as HPTP-eta or DEP-1) is a transmembrane protein tyrosin phosphatase containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leucocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.

Human

2°C to 8°C

12352203