anti-CD15 antibody [MEM-158]

Arigo Biolaboratories

anti-CD15 antibody [MEM-158]

23

Flow Cytometry, ImmunoPrecipitation, Other Application

Research Use Only

Monoclonal

MEM-158

1 mg/ml

Unconjugated

>95%

FUT4

fucosyltransferase 4

alpha (1,3) fucosyltransferase, myeloid-specific; alpha-(1,3)-fucosyltransferase 4; CD15; ELAM ligand fucosyltransferase; ELAM-1 ligand fucosyltransferase; ELFT; FCT3A; fucosyltransferase IV; FUC-TIV; fucT-IV; FUTIV; galactoside 3-L-fucosyltransferase; Lewis X; LeX; SSEA-1; stage-specific embryonic antigen 1

Mouse

IgM

CD15 (Lewis X, Le(x); stage specific embryonic antigen-1, SSEA-1) is a trisacharide determinant (3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumour cells. There are several variants of Lewis x, such as sialyl-Lewis x or sulphated Lewis x. Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. This process is involved for example in embryo compaction or in autoaggregation of teratocarcinoma cells. Sialyl-Le(x) and its isomer sialyl-Le(a) are ligands of selectins. CD15 expression has been extensively used to confirm diagnosis of Hodgkins disease.

Human

-20°C

12352203