Anti-CD156b [hz1022C3], Human IgG1, Fc Silent(tm), kappa

Absolute Antibody

Anti-CD156b [hz1022C3], Human IgG1, Fc Silent(tm), kappa

9

This antibody is specific for the membrane proximal domain of ADAM17.

The original antibody was used for an ELISA on human ADAM17 to determine its binding affinity. The antibody was used for flow cytometry on A172 human tumour cells to confirm that it could bind to cellular ADAM17. This antibody was used in vivo on mice in which A431 tumors were established, treatment with the antibody showed significant tumor inhibition and regression was observed in all animals, it achieved complete regression in two mice (US20180057601A1).

Flow Cytometry, ELISA, Other Application

Research Use Only

Monoclonal

hz1022C3

ADAM17

ADAM metallopeptidase domain 17

a disintegrin and metalloproteinase 17; ADAM metallopeptidase domain 18; ADAM18; cartilage snake venom-like protease; CD156B; CSVP; disintegrin and metalloproteinase domain-containing protein 17; NISBD; NISBD1; snake venom-like protease; TACE; TNF-alpha convertase; TNF-alpha convertase enzyme; TNF-alpha converting enzyme; tumor necrosis factor, alpha, converting enzyme

Human

IgG1

Disintegrin and metalloproteinase domain-containing protein 17

This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203