Anti-CD16 [DJ130c]

Absolute Antibody

Anti-CD16 [DJ130c]

7

This antibody recognises an epitope in the first membrane-distal domain of both CD16a and CD16b. CD16 is a low affinity receptor for IgG, and plays an important role in mediating ADCC by NK cells.

DJ130c may be used in identification and characterisation of various cancers. For instance, one group utilised this antibody in the analysis of expression profiles of gastric cancer xenografts exposed to cisplatin and considerable alteration in the expression level of CD16 was observed (Cai et al., 2017). Another group used this antibody to identify and compare different subpopulations of macrophages and their potential relation to acute heart transplant rejection, both via immunofluorescence and immunohistochemistry in tissue samples (van den Bosch et al., 2017).

Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry

IHC; IP; FC; WB

Research Use Only

Monoclonal

DJ130c

FCGR3A

Fc fragment of IgG receptor IIIa

CD16; CD16A; CD16a antigen; Fc fragment of IgG, low affinity III, receptor for (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Fc gamma receptor III-A; FCG3; Fc-gamma receptor III-2 (CD 16); Fc-gamma receptor IIIb (CD16); Fc-gamma RIII-alpha; FcgammaRIIIA; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3; igG Fc receptor III-2; IMD20; immunoglobulin G Fc receptor III; low affinity immunoglobulin gamma Fc region receptor III-A; low affinity immunoglobulin gamma receptor III-a Fc fragment; neutrophil-specific antigen NA

Human

IgG1

Low affinity immunoglobulin gamma Fc region receptor III-B

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

This antibody was raised by immunising mice with CD16 antigen.

-20°C,2°C to 8°C

12352203