Anti-CD16/CD32 [2.4G2]

Absolute Antibody

Anti-CD16/CD32 [2.4G2]

9

This antibody binds to an epitope on the extracellular domains of the mouse FcgammaIII and FcgammaII, thereby inhibiting their ability to bind antibodies via their Fc region. receptors. Also binding the FcgammaI receptor (CD64) via its Fc domain.

This antibody binds murine Fc Receptors CD16/CD32 and inhibits binding of antibodies to these. It can therefore be used as an Fc-blocking reagent, to reduce non-specific staining of cells by antibodies binding via their Fc-region. A similar effect can be achieved using the Fc Silent range of antibodies made by Absolute Antibody that prevent these interactions at the level of the Fc receptor binding site, which has been mutated to lack affinity for the Fc receptors.

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoHistoChemistry, Neutralisation/Blocking

Research Use Only

Monoclonal

2.4G2

Fcgr2b

Fc receptor, IgG, low affinity IIb

AI528646; CD32; F630109E10Rik; fc gamma receptor IIB; Fc gamma RIIB; Fc[g]; Fc[g]RII; Fcg; Fcgamm; fc-gamma RII; Fc-gamma-RII; FcgammaRIIB; fc-gamma-RIIB; Fcgr; Fcgr2; Fcgr2a; FcgRII; Fcr-; Fcr-2; Fcr-3; fcRII; igG Fc receptor II beta; low affinity immunoglobulin gamma Fc region receptor II; low affinity immunoglobulin gamma Fc region receptor II-b; Ly-1; Ly-17; LyM-; LyM-1; Ly-m2; Ly-m20; lymphocyte antigen 17

Rat

IgG2b

Low affinity immunoglobulin gamma Fc region receptor II

Mouse

12352203