anti-CD172a / SIRP alpha antibody

Arigo Biolaboratories

anti-CD172a / SIRP alpha antibody

23

Western Blot

Research Use Only

Polyclonal

Unconjugated

SIRPA

signal regulatory protein alpha

BIT; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; CD172 antigen-like family member A; CD172A; inhibitory receptor SHPS-1; macrophage fusion receptor; MFR; MYD-1; myd-1 antigen; P84; PTPNS1; SHPS1; SIRP; tyrosine phosphatase SHP substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1

Rabbit

IgG

Protein tyrosine phosphatases (PTPases), such as SHP-1 and SHP-2, are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse, and cattle by several laboratories and was designated SIRPalpha, SHPS-1, and MyD-1. SIRPalpha/SHPS-1 is a new gene family containing at least fifteen members. SIRPalpha/SHPS-1 is a substrate of manyactivated tyrosine kinases such as insulin receptor, EGFR, PDGFR, and src, and is a specific docking protein for SHP-2. SIRPalpha/SHPS-1 has regulatory effects on cellular responses induced by serum,growth factors, insulin, oncogenes, and cell adhesion and plays a general role in different physiological and pathological processes.

Bovine, Human, Mouse, Rat

-20°C

12352203