Anti-CD20 [VET308 (CD20-5)]

Absolute Antibody

Anti-CD20 [VET308 (CD20-5)]

9

This antibody binds canine (dog) CD20 and cross reacts with feline (cat) CD20. This protein plays an important role in the regulation of cellular calcium influx necessary for development, differentiation, and activation of B-lymphocytes.

The binding reactivity of this antibody to recombinant dog and cat CD20 expressed on the surface of CHO cells was determined using flow cytometry. This antibody binds recombinant dog CD20 with a binding affinity of Kd= 1.2 nM. This antibody exhibited a strong staining of B cells in a immunohistochemical staining of lymph node tissues collected from dogs with B-cell lymphoma. The ability of this antibody to alter the proliferation of lymphoma cells was checked using cell assays. This antibody was reported to cause a 60% reduction in proliferation of lymphoma cells (US9616120).

Functional Assay, Flow Cytometry, ImmunoHistoChemistry

Research Use Only

Monoclonal

VET308 (CD20-5)

MS4A1

membrane spanning 4-domains A1

B-lymphocyte antigen CD20; CD20; membrane-spanning 4-domains, subfamily A, member 1

Rabbit

IgG

B-lymphocyte antigen CD20

Canine, Feline

-20°C,2°C to 8°C

12352203