anti-CD200 antibody [OX-104] (PE)

Arigo Biolaboratories

anti-CD200 antibody [OX-104] (PE)

23

Flow Cytometry

Research Use Only

Monoclonal

OX-104

RPE

CD200

CD200 molecule

antigen identified by monoclonal antibody MRC OX-2; CD200 antigen; MOX1; MOX2; MRC; OX-2; OX-2 membrane glycoprotein

Mouse

IgG1

CD200 (also known as OX2 or MRC) is a type-1 membrane glycoprotein, which contains two extracellular immunoglobulin domains, transmembrane domain and cytoplasmic domain. It is expressed by neuronal cells, B and T cell subsets, follicular dendritic cells, keratinocytes, and ovarian cells. The interaction between CD200 and its receptor CD200R results in macrophage activation (IL-6 production), inhibition of mast cell degranulation along with reduced TNF-alpha and IL-13 secretion and overall attenuation of the activation status of lymphocytes. It seems CD200 is also involved in maternal tolerance and its decreased expression in hair follicle correlates with follicular miniaturization.

Human

2°C to 8°C

12352203