Anti-CD21 [THB-5]

Absolute Antibody

Anti-CD21 [THB-5]

7

This antibody is specific for human CD21 (complement receptor type 2), which is expressed on B-cells and participates in B cell activation. It recognises a distinct antigenic site to the anti-B2 antibody (Tedder et al, 1984).

The binding specificity of this antibody has been confirmed in flow cytometry and immunofluorescence analysis (Tedder et al, 1984), with only B cell reactivity observed. Though this antibody binds to CD21, which acts as a receptor for Epstein-Barr virus (EBV), it cannot alone block viral entry into B cells (Fingeroth et al, 1984). EBV virions engineered to express this antibody at their surface have been used to probe the need for CD21 binding to achieve viral entry (Busse et al, 2010).

Flow Cytometry, ImmunoFluorescence

IF; FC

Research Use Only

Monoclonal

THB-5

CR2

complement C3d receptor 2

C3DR; CD21; complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; complement receptor type 2; CR; CVID7; EBV receptor; SLEB9

Human

IgG1

Complement receptor type 2

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

This antibody was raised by immunising BALB/c mice with human B cells of the SB line. Spleen cells were then removed and fused with Ag8.653 myeloma cells, to produce stable hybridomas.

-20°C,2°C to 8°C

12352203