Anti-CD22 [To15]
Ab01315-3.0
ApplicationsFlow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetCD22
Overview
- SupplierAbsolute Antibody
- Product NameAnti-CD22 [To15]
- Delivery Days Customer7
- Antibody SpecificityThis antibody recognises epitope C on the fourth Ig-like domain of the human CD22. CD22 which is a representative of the immunoglobulin superfamiliy and binds sialylated ligands. Its involved in the interactions between B-cell interactions. It is higly ex
- Application Supplier NoteIP: To15 antibody was used for the immunoprecipitation of the products of IgM kinase reaction to examine association between CD22 and B-cell receptor (Peaker and Neurberger, 1993); another group was also successfull in using this abtybody for immunoprecipitation (Zhang and Varki, 2004). Furthermore, it was demonstrated that To15 antibody was able to block CD22-mediated adhesion (specifically, the binding of Daudi cells to COS-CD cells) in around 40% of cases, which presents a potential for using this antibody in CD22 inhibition in the immune disease (Tedder et al., 1996). IHC: This antibody was also used to co-stain histological samples of lymph node biopsies in an attempt to immunologically characterise Langerhans cells in lymph nodes (Ralfkiaer et al., 1984).
- ApplicationsFlow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry
- Applications SupplierIHC; FACS; IP; adhesion assays
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDTo15
- Gene ID933
- Target nameCD22
- Target descriptionCD22 molecule
- Target synonymsB-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; CD22 antigen; sialic acid-binding Ig-like lectin 2; SIGLEC2; SIGLEC-2; T-cell surface antigen Leu-14
- HostMouse
- IsotypeIgG2b
- Protein IDP20273
- Protein NameB-cell receptor CD22
- ReactivityHuman
- Reactivity SupplierHuman
- Reactivity Supplier NoteThis antobody was raised by immunising Balb-c mice with a potassium iodide extract of normal human tonsil cell membranes and subsequent creation of hybridomas.
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203