Anti-CD257 (BAFF) [NMB04]

Absolute Antibody

Anti-CD257 (BAFF) [NMB04]

9

This antibody binds human BAFF protein and cross reacts with mouse and cynomolgus monkey BAFF protein. B-cell-activating factor (BAFF/CD257) is a cytokine belonging to the tumour-necrosis factor (TNF) family. This cytokine binds to TNFRSF13B/TACI, TNFRSF1

This antibody is capable of inhibiting the Blys signaling pathway by binding to Blys to block its binding to the receptor. The blocking activity of this antibody was reported to be better than Belimumab. In vitro, this antibody inhibited Blys-stimulated B cell proliferation and also inhibited Blys-stimulated mouse splenocyte proliferation. The original IgG1 version of this antibody binds BLyS with a very high binding affinity of Kd= 7.38E-10M. This antibody significantly inhibited human BLYS-induced activation and proliferation of splenic B cells in vivo (CN105061596).

Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

NMB04

TNFSF13B

TNF superfamily member 13b

ApoL related ligand TALL-1; BAFF; B-cell-activating factor; B-lymphocyte stimulator; BLYS; CD257; delta BAFF; Delta4 BAFF; dendritic cell-derived TNF-like molecule; DTL; epididymis secretory sperm binding protein; TALL1; TALL-1; THANK; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; TNFSF20; TNLG7A; tumor necrosis factor (ligand) superfamily, member 13b; tumor necrosis factor (ligand) superfamily, member 20; tumor necrosis factor ligand 7A; tumor necrosis factor ligand superfamily member 13B; tumor necrosis factor superfamily member 13b; tumor necrosis factor-like protein ZTNF4; ZTNF4

Rabbit

IgG

Tumor necrosis factor ligand superfamily member 13B

Human, Monkey, Mouse

-20°C,2°C to 8°C

12352203