anti-CD261 / TRAIL R1 antibody [DR-4-02]

Arigo Biolaboratories

anti-CD261 / TRAIL R1 antibody [DR-4-02]

23

Functional Assay, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoCytoChemistry

Research Use Only

Monoclonal

DR-4-02

1 mg/ml

Unconjugated

>95%

TNFRSF10A

TNF receptor superfamily member 10a

APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAILR1; TRAIL-R1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a

Mouse

IgG1

TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues.Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).

Human

-20°C

12352203