anti-CD266 / TWEAK R antibody [ITEM-4] (low endotoxin)

Arigo Biolaboratories

anti-CD266 / TWEAK R antibody [ITEM-4] (low endotoxin)

23

Functional Assay, Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

ITEM-4

1 mg/ml

Unconjugated

>95%

TNFRSF12A

TNF receptor superfamily member 12A

CD266; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; FN14; tumor necrosis factor receptor superfamily member 12A; TWEAKR; tweak-receptor; type I transmembrane protein Fn14

Mouse

IgG2b

CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.

Human

-20°C

12352203