anti-CD268 / BAFF R antibody [2C4]

Arigo Biolaboratories

anti-CD268 / BAFF R antibody [2C4]

23

Flow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

2C4

1 mg/ml

Unconjugated

TNFRSF13C

TNF receptor superfamily member 13C

tumor necrosis factor receptor superfamily member 13C; tumor necrosis factor receptor superfamily, member 13C

Mouse

IgG1

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

Chicken

-20°C

12352203