Anti-CD277 [108.5]

Absolute Antibody

Anti-CD277 [108.5]

9

This antibody binds human CD277 (BTNA3A1). This protein plays an important role in T-cell activation and in the adaptive immune response. It regulates proliferation of activated T-cells and release of IFNG by activated T-cells. It is expressed on surface

This antibody was used as an antagonist antibody to check if BTN3A can specifically enhance Vg9Vd2 TCR-mediated lysis of primary AML blasts using cytotoxic assays. This antibody was reported to significantly and drastically abrogate zoledronate (ZOL)-induced lysis (PMID: 27853633). This antibody can completely abrogate Vgamma9Vdelta2 T cell mediated lysis of tumors (PMID: 29296524).

Functional Assay, Other Application

Research Use Only

Monoclonal

108.5

BTN3A1

butyrophilin subfamily 3 member A1

BT3.1; BTF5; BTN3.1; butyrophilin subfamily 3 member A1; CD277; dJ45P21.3 (butyrophilin, subfamily 3, member A1)

Rabbit

IgG

Butyrophilin subfamily 3 member A1

Human

-20°C,2°C to 8°C

12352203