anti-CD3 antibody [CA17.2A12]

Arigo Biolaboratories

anti-CD3 antibody [CA17.2A12]

23

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

CA17.2A12

1 mg/ml

Unconjugated

CD3E

CD3e molecule

CD3 epsilon; CD3E antigen, epsilon polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 epsilon chain

Mouse

IgG1

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.

Canine

-20°C

12352203