Anti-CD4, Cytoplasmic tail [10C12]

Absolute Antibody

Anti-CD4, Cytoplasmic tail [10C12]

7

This antibody recognises LSEKKTCQCPHRFQKTCSPI peptide of human CD4 epitope within amino acids 414 and 433 of the cytoplasmic tail region. CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigen

10C12 antibody reacts with a poorely studied tail region of human CD4 and might be used to conduct reasearch on the role of this fragment of the protein. Furthermore, this antibody can be used for studies on expression of CD4. One group utilised 10C12to perform Western blot analysis of CD4 expression in cerebellar granule neurons when researching interleukin-16 induced c-Fos expression (Fenster et al., 2010). This antibody may be also used as an effective blocking agent inhibiting Il-16 (Atanackovic et al., 2012). Finally, 10C12 has also been recommended for studies of the role of selenium metabolism and selenoproteins in diseases, such as infectious diseases (HIV) and cancer (Ware, 2003).

ImmunoFluorescence, Western Blot, ELISA, Neutralisation/Blocking

ELISA; IF; WB; blocking

Research Use Only

Monoclonal

10C12

CD4

CD4 molecule

CD4 antigen (p55); CD4 receptor; CD4mut; IMD79; OKT4D; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4

Rabbit

IgG

T-cell surface glycoprotein CD4

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

This antibody was raised against a multiple antigenic peptide; a tetramer linked through a lysine backbone.

-20°C,2°C to 8°C

12352203