Anti-CD4 [MT310]

Absolute Antibody

Anti-CD4 [MT310]

9

This antibody is specific for the CD4 extracellular domain D1 (binding the HIV-1 gp120-binding site).

This antibody strongly inhibits HIV-1 gp120-binding to CD4, which blocks HIV infectivity of CD4+ T lymphocytes, as well as the binding of MHCII, which results in the block of T-cell activation (possibly leading to anergy induction) (Qin et al., 2001; PMID: n/a). Additionally, antibody binding to CD4 leads to GM-CSF, TNF-alpha and IL-10 induction. (TNF-alpha induction only occurs after 20 hours.)

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking

Research Use Only

Monoclonal

MT310

CD4

CD4 molecule

CD4 antigen (p55); CD4 receptor; CD4mut; IMD79; OKT4D; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4

Human

IgG1

T-cell surface glycoprotein CD4

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human, Monkey, Primate

-20°C,2°C to 8°C

12352203