Anti-CD4 [OX-38]

Absolute Antibody

Anti-CD4 [OX-38]

9

This antibody binds rat CD4 cell surface antigen. CD4 is a transmembrane glycoprotein expressed on T helper cells, thymocytes, monocytes and macrophages. It plays an important role in the response of T helper cells to antigen. This antibody binds an ident

This antibody can be used to identify CD4 antigen present on T cells, thymocytes, monocytes etc. using flow cytometry. This antibody was also able to immunoprecipitate detergent extracts of iodine 125 labeled thymocytes (PMID: 3159821). This antibody can be used for the in vitro depletion of T helper cells from slice cultures in studies looking for myelin loss in multiple sclerosis, the observed disruption being abrogated in these experimental conditions by T-cell depletion (PMID: 25500111). This antibody was tested for its ability to prolong the survival of heterotopic vascularized rat heart allografts transplanted across major histocompatibility barriers. Nine of 12 treated rats have maintained heterotopic abdominal heart allografts for greater than 175 days (PMID: 1976282). This antibody was used in a study to demonstrate that monoclonal antibody-induced depletion of CD4 helper/inducer T lymphocytes before transplantation of a fully mismatched heart allograft allows permanent engraftment in rats without further immunosuppression (PMID: 1977898).

Flow Cytometry, ImmunoPrecipitation

Research Use Only

Monoclonal

OX-38

Cd4

Cd4 molecule

CD4 antigen; p55; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; W3/25; W3/25 antigen

Rabbit

IgG

T-cell surface glycoprotein CD4

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format for improved compatibility with existing reagents assays and techniques.

Rat

-20°C,2°C to 8°C

12352203