Anti-CD4 [YKIX302.9]

Absolute Antibody

Anti-CD4 [YKIX302.9]

7

This antibody is specific for the canine CD4 cell surface antigen, which, in contrast to other mammals, is expressed by neutrophils as well as lymphocyte subsets.

This antibody recognizes canine CD4, which binds MHC II, and has been shown to block MHC II-dependent T cell responses in vivo and in vitro. In a canine transplant model, administration of this antibody has been demonstrated to partially deplete circulating T lymphocytes, but alone was not sufficient to prolong allograft survival (Watson, 1993). This antibody is one of a panel of anti-canine monoclonal antibodies can be used in the evaluation of leukemic status in dogs. This antibody has been used in IF and IP analysis to identify the canine homologue of human CD4 (Cobbold, 1994).

Flow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

FC; IHC; IHC-fr

Research Use Only

Monoclonal

YKIX302.9

CD4

CD4 molecule

CD4 antigen (p55); T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4

Canine

IgG2

T-cell surface glycoprotein CD4

This chimeric dog antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Canine

Dog

This antibody was prepared by immunizing rats with concanavilin A activated T-cell blasts

-20°C,2°C to 8°C

12352203