anti-CD42a antibody [GR-P]

Arigo Biolaboratories

anti-CD42a antibody [GR-P]

23

Flow Cytometry

Research Use Only

Monoclonal

GR-P

1 mg/ml

Unconjugated

>95%

GP9

glycoprotein IX platelet

CD42a; glycoprotein 9; GPIX; platelet glycoprotein IX

Mouse

IgG1

CD42a, also known as Glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.

Human

-20°C

12352203