Anti-CD44v6 [BIWA8]

Absolute Antibody

Anti-CD44v6 [BIWA8]

9

The antibody is specific for CD44v6. CD44v6 is a tumor associated antigen abundantly expressed in head and neck squamous cell carcinomas (HNSCC) and in normal squamous epithelium.

The antibody is the mutated version of BIWA-4 that was constructed with the aim of improving binding affinity. The binding affinity of the antibody to CD44v6 was measured by surface plasmon resonance. The antibody showed a specificity of tumor localization when administrated together with another anti-CD44v6 antibody to mice in in vivo experiments (Verel et al. 2002; PMID: 11992408). The specificity of the humanized version of the antibody was confirmed by ELISA anlaysis (Kd= 0.84 nM). The antibody had good therapeutic efficacy in in vivo experiments in mice. Mice treated with labelled 186Re-BIWA 8 showed a decreased in the tumor volume (US6972324B2).

Other Application

Research Use Only

Monoclonal

BIWA8

CD44

CD44 molecule (Indian blood group)

CD44 antigen; CDW44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; CSPG8; ECMR-III; epican; extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HCELL; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronate receptor; IN; Indian blood group antigen; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; phagocytic glycoprotein 1; soluble CD44

Rabbit

IgG

CD44 antigen

Human

-20°C,2°C to 8°C

12352203