anti-CD45 antibody [YKIX716.13] (PE)

Arigo Biolaboratories

anti-CD45 antibody [YKIX716.13] (PE)

23

Flow Cytometry

Research Use Only

Monoclonal

YKIX716.13

RPE

PTPRC

protein tyrosine phosphatase receptor type C

CD45; CD45 antigen; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C; receptor-type tyrosine-protein phosphatase C

Rat

IgG2b

CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

Canine

2°C to 8°C

12352203