Anti-CD47 [C47B227]

Absolute Antibody

Anti-CD47 [C47B227]

7

The antibody is specific for CD47. The antibody binds a conformational epitope composed of residues in the CC loop (L54) and B-strand C* (K56 and T58) regions.

The structure of the Fab fragment in complex with CD47 was determined. The binding affinity of the antibody to human and cyno CD47 were measured (Kd= 1nM and 0,5 nM respectively). The antibody inhibited CD47 from interacting with SIRP alpha (US10864268).

Neutralisation/Blocking, Other Application

Crystallography; Inhibition

Research Use Only

Monoclonal

C47B227

CD47

CD47 molecule

antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; CD47 antigen (Rh-related antigen, integrin-associated signal transducer); CD47 glycoprotein; IAP; integrin associated protein; integrin-associated signal transducer; leukocyte surface antigen CD47; MER6; OA3; Rh-related antigen

Rabbit

IgG

Leukocyte surface antigen CD47

Human

Human

Three de novo phage libraries displaying Fab variants on phage coat protein pIX were panned against biotinylated human CD47.

-20°C,2°C to 8°C

12352203