Anti-CD47 [mIAP301]

Absolute Antibody

Anti-CD47 [mIAP301]

9

MIAP301 binds specifically to the extracellular domain of CD47 (exon 2 that encodes both the predicted signal peptide clevage site and the entire Ig domain). CD47 plays a role in cell adhesion by acting as an adhesion receptor for THBS1 on platelets and i

MIAP301 can block murine CD47 interactions with SIRPalpha and functionally blocks CD47 in vivo in murine soft tissue ischemia and skin graft models (Soto-Pantoja et al. 2012). This antibody has also been used for FC (Olsson et al. Blood. 2005 May 1; 105(9): 3577-3582.). MIAP301 has also been shown to block KCl-evoked glutamate release from the hippocampus in mice, inhibiting glutamate release and thus impair memory retention (Chang et al. 2001).

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, Neutralisation/Blocking

Research Use Only

Monoclonal

mIAP301

Cd47

CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

9130415E20Rik; AA407862; AI848868; AW108519; B430305P08Rik; IAP; integrin-associated protein; It; Itgp; leukocyte surface antigen CD47; Rh-related antigen

Rat

IgG2a

Leukocyte surface antigen CD47

Mouse

-20°C,2°C to 8°C

12352203