Anti-CD53 [161-2 (53/2)]

Absolute Antibody

Anti-CD53 [161-2 (53/2)]

7

This antibody recognizes human CD53. It does not react with the baboon and horse antigen. Cd53 is a member of tetraspanin family and is involved in cellular activation as part of a signal transduction complex involving other membrane glycoproteins.

This antibody is recommended for the detection and analysis of CD53 via flow cytometry and immunofluorescence. Additionally, one group utilized this antibody for the ligation of the CD53 antigen while researching the potential involvement of tetraspanins (such as CD53) in tumor metastasis (Yunta et al., 2002). Furthermore, CD53 appears to be the marker with widest reactivity as well as the marker with the strictest specificity to hematopoietic cells, as it is expressed on monocytes and macrophages, dendritic cells, osteoblasts and osteoclasts, and on T and B cells from every stage of differentiation but is absent from platelets, red blood cells.

Functional Assay, Flow Cytometry, ImmunoFluorescence

FC; IF; functional studies

Research Use Only

Monoclonal

161-2 (53/2)

CD53

CD53 molecule

antigen MOX44 identified by monoclonal antibody MRC-OX44; CD53 antigen; CD53 glycoprotein; CD53 tetraspan antigen; cell surface antigen; cell surface glycoprotein CD53; leukocyte surface antigen CD53; MOX44; tetraspanin-25; transmembrane glycoprotein; TSPAN25; tspan-25

Human

IgG1

Leukocyte surface antigen CD53

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

This antibody was raised by immunizng mice with stimulated human leukocytes.

-20°C,2°C to 8°C

12352203