Anti-CD64 [H22]

Absolute Antibody

Anti-CD64 [H22]

9

This antibody is specific for human CD64, specifically an epitope outside the Fc binding domain. The binding activity of the VH/VL antibody format was unaffected by the fusion of the m22(scFv) coding regions to the truncated ETA coding sequences.

This antibody binds human CD64 and can be bound to a toxin so that together it displays specific cytotoxicity, and thus can be used to selectively eliminate AML cells; FC analysis indicated that this immunotoxin drove 41% of primary leukemia cells from a patient with CD64-positive AML into early apoptosis (Tur, 2003). Similarly, in an in vivo mouse model, IHC analysis revealed efficient elimination of human CD64+ tumor cells in mouse organs (Tur, 2011).

Flow Cytometry, ELISA, Other Application

Research Use Only

Monoclonal

H22

FCGR1A

Fc fragment of IgG receptor Ia

CD64; CD64A; Fc fragment of IgG, high affinity Ia, receptor (CD64); Fc fragment of IgG, high affinity Ia, receptor for (CD64); Fc gamma receptor Ia; Fc-gamma receptor I A1; Fc-gamma RI; fc-gamma RIA; FcgammaRI; fcgammaRIa; FCRI; high affinity immunoglobulin gamma Fc receptor I; IGFR1; IgG Fc receptor I

Human

IgG1

High affinity immunoglobulin gamma Fc receptor I

This is a reformatted Fc Silent™ antibody based on the original Human IgG1 antibody, created for improved compatibility with existing reagents, assays, and techniques.

Human

-20°C,2°C to 8°C

12352203