Anti-CD66b [BW 250/183]

Absolute Antibody

Anti-CD66b [BW 250/183]

9

This antibody binds the human CD66b, which is expressed on the surface of granulocytes.

This murine antibody reacted with granulocytes, colon mucosa and faintly with pancreatic ducts (PMID: 2410375). The radioactive isotope technetium-99m labelled version of this antibody is also called Besilesomab (trade name Scintimun). It has been studied widely for therapeutic applications. Technetium-99m-Labeled BW 250/183 was used to study the inflamatory process and identification of the inflamatory foci using immunoscintigraphy (PMID: 2157831, 1565572). This antibody is also used for scintiographic imaging of soft tissue infections, peripheral bone, and abdominal infections (PMID: 8023170). Tc-99m-labeled antibody has also been used in the localization of extramedullary hematopoiesis (PMID: 11953571). Rhenium-188-labelled BW250/183 was developed for adjuvant conditioning radioimmunotherapy of bone marrow before bone marrow transplantation. Immunoreactivity of the reduced and rhenium-incorporated antibody was determined by indirect immunofluorescence, by means of a whole blood staining method follwoed by flow ctometric analysis (PMID: 10541824). 90Y-label is reportedled antibody is reported to be used in the study of expression of CD66b in non-Hodgkin lymphomas and multiple myeloma usinf flow cytometry (PMID: 20887387).

Flow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry

Research Use Only

Monoclonal

BW 250/183

CEACAM8

CEA cell adhesion molecule 8

carcinoembryonic antigen CGM6; carcinoembryonic antigen gene family member 6; carcinoembryonic antigen related cell adhesion molecule 8; carcinoembryonic antigen-related cell adhesion molecule 8; CD66b; CD67; CD67 antigen; CGM6; NCA-95; non-specific cross-reacting antigen NCA-95

Mouse

IgG1

Carcinoembryonic antigen-related cell adhesion molecule 8

Human

-20°C,2°C to 8°C

12352203