Anti-CD7 [T3-3A1]

Absolute Antibody

Anti-CD7 [T3-3A1]

7

This antibody binds human CD7. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. CD7 is useful in the ide

This antibody is capable of recognizing CD7 antigen present on various T cell lines like n HSB-2, HPB-MLT, MOLT-4, CEM, and TALL-1. This antibody also bound a majority (85%) of human PB E-rosette-positive cells. Immunoprecipitation of an HSB-2 extract with this antibody yielded one specific band with a molecular weight of approximately 40,000 in the presence of reducing agent (PMID: 6156457). This antibody was also used in the development of a cell ELISA to monitor the PHA-induced expression of the CD7 antigen in fixed mononuclear leukocytes (PMID: 3492562). This antibody was also used in combination with another anti-CD7 antibody mab 69 of development of a sandwich ELISA for detection of solubilized CD7 antigen (PMID: 2464646). This antibody was used in a study relating to identifying CD7 as target structure for T-cell imaging. Noninvasive CD7 immuno-imaging is a promising strategy to track T-cell responses in the context of diverse immunotherapies in vivo with additional theragnostic potential in T-cell-mediated diseases (PMID: 30613283).

Flow Cytometry, ImmunoPrecipitation, ELISA

ELISA; IP; FC

Research Use Only

Monoclonal

T3-3A1

CD7

CD7 molecule

CD7 antigen (p41); GP40; LEU-9; p41 protein; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41

Human

IgG1

T-cell antigen CD7

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

Human

The original antibody was generated by immunizing female BALB/c mice both intravenously and intraperitoneally with HSB-2 T cells.

-20°C,2°C to 8°C

12352203