Anti-CD70 [LD70]

Absolute Antibody

Anti-CD70 [LD70]

9

This antibody binds human CD70, a cytokine belonging to the tumor necrosis factor (TNF) ligand family, which acts as a ligand for TNFRSF27/CD27. It is a surface antigen present on activated T and B cells. The CD70-CD27 pathway plays an important role in t

This antibody block the binding of CD70 to CD21. This blocking effect was tested using the scFv version and it was reported that it was capable of blocking the binding of recombinant CD70-Fc to CD21 coated on ELISA plates. This antibody was also reported to have inhibitory effect on the growth of breast cancer cells in vitro. The in vivo inhibitory activity of this antibody was tested in mice infected with breast cancer cells MDA-MB-231. It was further reported that this antibody could inhibit tumor growth in vivo (CN109021106).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

LD70

CD70

CD70 molecule

CD27 ligand; CD27L; CD27-L; CD27LG; CD70 antigen; Ki-24 antigen; LPFS3; surface antigen CD70; TNFSF7; TNLG8A; tumor necrosis factor ligand 8A; tumor necrosis factor ligand superfamily member 7

Mouse

IgG2b

CD70 antigen

Human

-20°C,2°C to 8°C

12352203