Anti-CD79a [JCB117]

Absolute Antibody

Anti-CD79a [JCB117]

9

This antibody recognises CD79a which is involved in initiation of the signal transduction cascade activated by binding of antigen to the B-cell receptor. CD79a is used as an adjunct to CD20 for detecting normal and neoplastic B cells in tissue sections.

This antibody reacts very well with B-cells during immunohistochemical labelling of paraffin-embedded tissue samples. It detected most B-cell neoplasms tagging B-cells at various stages of maturation (Mason et al., 1995). Consequently, it may be used as a reliable marker in the detection and investigation of different B-cell conditions. For instance, it labels precursor B-cell acute lymphoblastic leukemia samples what makes it the most efficient marker of this disorder in paraffin-embedded tissue (Mason et al., 1995). Furthermore, this antibody may be useful in staining and identification of plasma cell myeloma and acute promyelocytic leukemia. For example, JCB117 antibody was utilised in the characterisation of multiple myeloma and it showed very strong immunostaining of the neoplastic cells (Requena et al., 2003).

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

JCB117

CD79A

CD79a molecule

B-cell antigen receptor complex-associated protein alpha chain; CD79a antigen (immunoglobulin-associated alpha); CD79a molecule, immunoglobulin-associated alpha; IGA; ig-alpha; MB-1; MB-1 membrane glycoprotein; membrane-bound immunoglobulin-associated protein; surface IgM-associated protein

Human

IgG4

B-cell antigen receptor complex-associated protein alpha chain

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203