anti-CD8b antibody [341] (FITC)
ARG65387
ApplicationsFlow Cytometry
Product group Antibodies
TargetCd8b
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-CD8b antibody [341] (FITC)
- Delivery Days Customer23
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID341
- Concentration0.5 mg/ml
- ConjugateFITC
- Gene ID24931
- Target nameCd8b
- Target descriptionCD8b molecule
- Target synonymsCD8 antigen 37 kDa chain; CD8 antigen beta-chain; Cd8b1; OX-8 membrane antigen; T-cell surface glycoprotein CD8 beta chain
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
- Storage Instruction2°C to 8°C
- UNSPSC12352203