anti-CDK4 antibody

Arigo Biolaboratories

anti-CDK4 antibody

23

Western Blot

Research Use Only

Monoclonal

1 mg/ml

Unconjugated

CDK4

cyclin dependent kinase 4

cell division protein kinase 4; CMM3; cyclin-dependent kinase 4; PSK-J3

Mouse

IgG1

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Human

-20°C

12352203