anti-Cellular Apoptosis Susceptibility antibody
ARG55082
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Zebra Fish
TargetCSE1L
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-Cellular Apoptosis Susceptibility antibody
- Delivery Days Customer23
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID1434
- Target nameCSE1L
- Target descriptionchromosome segregation 1 like
- Target synonymsCAS; cellular apoptosis susceptibility protein; chromosome segregation 1-like protein; CSE1; CSE1 chromosome segregation 1-like; epididymis secretory sperm binding protein; exp2; exportin-2; importin-alpha re-exporter; XPO2
- HostRabbit
- IsotypeIgG
- Scientific DescriptionProteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
- ReactivityBovine, Human, Zebra Fish
- Storage Instruction-20°C
- UNSPSC12352203