Western blot: rat brain lysate ARG52243 anti-ChAT antibody showing specific immunolabeling of the ~68/70k ChAT
Western blot: rat brain lysate ARG52243 anti-ChAT antibody showing specific immunolabeling of the ~68/70k ChAT
anti-ChAT antibody
ARG52243
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetCHAT
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-ChAT antibody
- Delivery Days Customer23
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID1103
- Target nameCHAT
- Target descriptioncholine O-acetyltransferase
- Target synonymsacetyl CoA:choline O-acetyltransferase; CHOACTASE; choline acetylase; choline O-acetyltransferase; CMS1A; CMS1A2; CMS6
- HostRabbit
- IsotypeIgG
- Scientific DescriptionCholine acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203