Anti-Citrullinated collagen type II [ACC1]

Absolute Antibody

Anti-Citrullinated collagen type II [ACC1]

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This antibody binds triple helical citrullinated form of C1 epitope (amino acids 359 - 369 : ARGLTGRPGDA) of collagen type II. The ACC1 antibody cross reacts with denatured CII as well as the denatured triple helical C1 epitope. C1 peptide contains two ar

Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). The binding specificity of mouse IgG2a version of this antibody towards citrullinated protein was determined through ELISA. This antibody was also used in the immunohistochemical staining of cartilage in paw samples obtained of arthritis induced mice. This antibody was also reported to induce and mediate arthritis in mice (PMID: 19204106). This antibody was also reported to cross react with noncitrullinated epitopes on native CII, causing proteoglycan depletion of cartilage and severe arthritis in mice. A study demonstrated the molecular mechanism on how ACC1 trigger arthritis (PMID: 28679953). This antibody was also used in the preparation of a cocktail for induction of rheumatoid arthritis in mice (PMID: 32448385).

ELISA, ImmunoHistoChemistry

Research Use Only

Monoclonal

ACC1

COL2A1

collagen type II alpha 1 chain

alpha-1 type II collagen; ANFH; AOM; arthroophthalmopathy, progressive (Stickler syndrome); cartilage collagen; chondrocalcin; COL11A3; collagen alpha-1(II) chain; collagen II, alpha-1 polypeptide; collagen, type II, alpha 1; SEDC; STL1

Mouse

IgG2a

Collagen alpha-1(II) chain

Bovine, Human, Mouse

-20°C,2°C to 8°C

12352203