Anti-Citrullinated collagen type II [ACC4]

Absolute Antibody

Anti-Citrullinated collagen type II [ACC4]

9

This antibody binds the citrullinated C1 epitope (amino acids 359 - 369 : ARGLTGRPGDA) as an alpha-chain peptide of the collagen type II and also shows binding affinity for the cyclic citrullinated filaggrin peptide. C1 peptide contains two arginines whic

Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). The binding specificity of mouse IgG1 version of this antibody towards citrullinated protein was determined through ELISA. This antibody was also used in the immunohistochemical staining of inflamed synovial tissue in the vicinity of cartilage in paw samples obtained from arthritis induced mice. This antibody was also reported to mediate arthritis in mice. ACC4 does not bind cartilage and cannot induce arthritis, but it can enhance the development of arthritis. The antibody is arthritogenic in combination with antibody M2139. Infusion of ACC4 induces collagen antibody-induced arthritis (CAIA) in the presence of the anti-Col II antibody M2139 (PMID: 19204106).

ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

ACC4

COL2A1

collagen type II alpha 1 chain

alpha-1 type II collagen; ANFH; AOM; arthroophthalmopathy, progressive (Stickler syndrome); cartilage collagen; chondrocalcin; COL11A3; collagen alpha-1(II) chain; collagen II, alpha-1 polypeptide; collagen, type II, alpha 1; SEDC; STL1

Rabbit

IgG

Collagen alpha-1(II) chain

This chimeric rabbit antibody was made using the variable domain sequences of the original murine IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human, Mouse

-20°C,2°C to 8°C

12352203