Anti-Claudin-18.2 [2C6.9]

Absolute Antibody

Anti-Claudin-18.2 [2C6.9]

9

This antibody is specific for human claudin-18.2. Alterations in claudin expression can impair tight junction function, influence signaling pathways, and act as a tumor-promoting event in some epithelial cancers. Claudin 18.2 is overexpressed in various t

This antibody can be used for the detection of human claudin 18.2. This antibody was also used in the generation of a CAR-T cell receptor. CLDN18.2 CAR-T specifically binds to tumor cells, activated 2C6.9-T-PD-1 CAR-T alleviates or eliminates immunosuppression by secreting anti-PD-1 antibodies, increasing the anti-tumor effect. 2C6.9-T can activate primary T cells and efficiently mediate the killing of tumor cells expressing CLDN18.2 by T cells and caused a significant increase in cytokine secretion (CN113754780).

Functional Assay

Research Use Only

Monoclonal

2C6.9

CLDN18

claudin 18

claudin-18; SFTA5; SFTPJ; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J

Rabbit

IgG

Claudin-18

Human

-20°C,2°C to 8°C

12352203