anti-CLOCK / KAT13D antibody

Arigo Biolaboratories

anti-CLOCK / KAT13D antibody

23

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

>95%

CLOCK

clock circadian regulator

bHLHe8; circadian locomoter output cycles kaput protein; circadian locomoter output cycles protein kaput; class E basic helix-loop-helix protein 8; clock homolog; KAT13D

Rabbit

IgG

The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Human

-20°C

12352203