Anti-Cn2 toxin [6009F]

Absolute Antibody

Anti-Cn2 toxin [6009F]

9

This antibody binds the mammal-specific Cn2 toxin found in the venom produced by Centruroides noxius Hoffmann (Mexican scorpion). This antibody binds an epitope on the Cn2 toxin that is different from the binding epitope of another anti-Cn2 toxin antibody

The binding specificity and characterization of this antibody towards Cn2 toxin of scorpion Centruroicles noxius was tested using ELISA. The epitope mapping of this antibody was performed using competitive ELISA. The scFv version of this antibody binds Cn2 toxin with an affinity of 410pM and capable of neutralizing 2 LD50 of Cn2 toxin when a 1 : 10 molar ratio of toxin-to-antibody fragment was used. It was also able to neutralize 2 LD50 of the whole venom (PMID: 15885107; US7381802). ELISA was also used to determine the cross- reactivity of this antibody towards other toxins like Cn3, Css2, and Css4 (PMID: 21156801).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

6009F

Rabbit

IgG

Beta-mammal toxin Cn2

This full-length chimeric rabbit antibody was made using the variable domain sequences of the original Human scFv format for improved compatibility with existing reagents assays and techniques.

Other Species

-20°C,2°C to 8°C

12352203