Anti-Complement C3b-iC3b [5G9]

Absolute Antibody

Anti-Complement C3b-iC3b [5G9]

9

This antibody is specific for complement C3b-iC3b. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can

This antibody has been shown to inhibit the CPC-mediated lysis of PNH erythrocytes in humans (Lindorfer et al, 2016; pmid:20068220). A CDC assay was preformed using this antibody on human Burkitts lymphoma cell lines, Daudi, Raji, Z138 mantle cell lymphoma cell lines and diffuse large B cell lymphoma cell line SU-DHL-4 (Beurskens et al, 2012; pmid:22368276). This antibody can also be used for flow cytometry and neutralizing applications.

Functional Assay, Flow Cytometry, Neutralisation/Blocking

Research Use Only

Monoclonal

5G9

C3

complement C3

acylation-stimulating protein cleavage product; AHUS5; ARMD9; ASP; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3a; C3a anaphylatoxin; C3b; complement C3; complement component 3; complement component C3a; complement component C3b; CPAMD1; epididymis secretory sperm binding protein Li 62p; HEL-S-62p; prepro-C3

Mouse

IgG2a

Complement C3

Human, Primate

-20°C,2°C to 8°C

12352203