Anti-Complement Factor D [I8/1]

Absolute Antibody

Anti-Complement Factor D [I8/1]

9

I8/1 antibody recognizes human complement factor D. Complement factor D is a serine protease of the alternative pathway of complement activation.Factor D cleaves factor B bound to C3b, generating the alternative pathway C3 convertase C3bBb and releasing t

I8/1 antibody can be used for the identification of the complement factor D from human serum and plasma. For instance, this antibody was utilized in the quantitation of the factor D levels in blood of patients with renal failure via a senstive ELISA procedure (Oppermann et al., 1991). It is particularly useful as factor D plasma levels positively correlate with plasma creatinine and the creatinine clearance in patients with chronic renal failure (Volanakis et al., 1985; Grubb et al., 1985).

Western Blot, ELISA

Research Use Only

Monoclonal

I8/1

CFD

complement factor D

ADIPSIN; ADN; C3 convertase activator; complement factor D; complement factor D preproprotein; D component of complement (adipsin); DF; PFD; properdin factor D

Human

IgG4

Complement factor D

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203