Anti-Crotonyllysine Mouse mAb

PTM BIO

Anti-Crotonyllysine Mouse mAb

5

Anti-Crotonyllysine Mouse mAb detects proteins with crotonylated lysine residues. This pan antibody recognizes crotonylated lysine independent of its surrounding sequences.

Western Blot

WB

Antibody

Research Use Only

Monoclonal

4D5

Unconjugated

Mouse

IgG

Lysine crotonylation is a newly-identified histone post-translational modification that has come to light through integrated proteomic approaches and elaborate biochemistry analyses. Lysine crotonylation has been found to be evolutionarily conserved across multiple species, spanning both prokaryotes and eukaryotes, and occurs in a wide range of proteins, incuding histones and non-histone substrates. The unique structure and genomic localization of lysine crotonylation suggest that it is mechanistically and functionally different from lysine acetylation. Given the revealed roles of lysine crotonylation in spermatogenesis, the novel modification may play important roles in multiple cellular pathophysiological processes by exerting its effects on chromatin structure and epigenetic pathways.

Stable for 12 months from date of receipt/reconstitution.

All Species

All

Protein G and immunogen affinity purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203