Anti-CTGF [HL2180 [17-73-D6]]

Absolute Antibody

Anti-CTGF [HL2180 [17-73-D6]]

9

This antibody binds aa 181-197 of hCTGF corresponding to the hinge region. It was also shown to stain rabbit CTGF in IHC. CTGF is a cysteine-rich, matrix-associated, heparin-binding protein. In vitro, CTGF mediates some of the effects of TGF-beta on skin

Proteolytically generated fragments of CTGF that retain functionality have been measured in biological fluids; this monoclonal antibody was designed with the intention to: a) discern between cleaved and uncleaved forms on the basis of a loss of immunoreactivity after cleavage (i.e. aa 187-197). This clone HL2180 [17-73-D6] binds specifically to the hinge region. b) Develop a sandwich ELISA using two mAbs per fragment, where one mAb is the capture antibody and the other is the detector (together with our non-competitive clones Ab02552 (HL2181) and Ab02553 (HL2198) which recognize distinct regions of CTGF. This antibody can be also used to detect CTGF in tissues via immunohistochemistry.

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Monoclonal

HL2180 (17-73-D6)

CCN2

cellular communication network factor 2

CCN family member 2; connective tissue growth factor; CTGF; HCS24; hypertrophic chondrocyte-specific protein 24; IBP-8; IGF-binding protein 8; IGFBP8; IGFBP-8; insulin-like growth factor-binding protein 8; NOV2

Human

IgG1

Connective tissue growth factor

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Human, Rabbit

-20°C,2°C to 8°C

12352203