Bio-Connect

Anti-CXCL10 [CC21R3P1_F1 (CC_F1)]

AB03437-23.0-BT
Absolute Antibody
ApplicationsFunctional Assay, ELISA
Product group Antibodies
ReactivityHuman
TargetCXCL10
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Overview

  • Supplier
    Absolute Antibody
  • Product Name
    Anti-CXCL10 [CC21R3P1_F1 (CC_F1)]
  • Delivery Days Customer
    9
  • Antibody Specificity
    This antibody binds human CXCL10. This pro-inflammatory cytokine is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic
  • Application Supplier Note
    The binding characterization of this antibody was done using ELISA. The binding affinity of this antibody towards human CXCL10 was determined using BIACORE and was found to be Kd= 9.2 nM. The neutralizing potential of the IgG version of this antibody on hCXCL10-induced calcium flux or cell chemotaxis was evaluated using the cell-based assays. This antibody was reported to inhibit the activity of both recombinant and native hCXCL10 in a dose-dependent manner. CXCL10 is able to oligomerize and bind to glycosaminoglycans (GAG) expressed at surface of cells such as endothelial cells. This antibody was capable of binding human CXCL10 immobilized on glycosaminoglycan (US7786268).
  • Applications
    Functional Assay, ELISA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    CC21R3P1_F1 (CC_F1)
  • Gene ID3627
  • Target name
    CXCL10
  • Target description
    C-X-C motif chemokine ligand 10
  • Target synonyms
    10 kDa interferon gamma-induced protein; C7; crg-2; C-X-C motif chemokine 10; gamma IP10; gIP-10; IFI10; INP10; interferon-inducible cytokine IP-10; IP-10; mob-1; protein 10 from interferon (gamma)-induced cell line; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member 10; small-inducible cytokine B10
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP02778
  • Protein Name
    C-X-C motif chemokine 10
  • Scientific Description
    This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.
  • Reactivity
    Human
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203