Anti-CXCL10 [CC21R3P1_F1 (CC_F1)]
AB03437-23.0-BT
ApplicationsFunctional Assay, ELISA
Product group Antibodies
ReactivityHuman
TargetCXCL10
Overview
- SupplierAbsolute Antibody
- Product NameAnti-CXCL10 [CC21R3P1_F1 (CC_F1)]
- Delivery Days Customer9
- Antibody SpecificityThis antibody binds human CXCL10. This pro-inflammatory cytokine is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic
- Application Supplier NoteThe binding characterization of this antibody was done using ELISA. The binding affinity of this antibody towards human CXCL10 was determined using BIACORE and was found to be Kd= 9.2 nM. The neutralizing potential of the IgG version of this antibody on hCXCL10-induced calcium flux or cell chemotaxis was evaluated using the cell-based assays. This antibody was reported to inhibit the activity of both recombinant and native hCXCL10 in a dose-dependent manner. CXCL10 is able to oligomerize and bind to glycosaminoglycans (GAG) expressed at surface of cells such as endothelial cells. This antibody was capable of binding human CXCL10 immobilized on glycosaminoglycan (US7786268).
- ApplicationsFunctional Assay, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDCC21R3P1_F1 (CC_F1)
- Gene ID3627
- Target nameCXCL10
- Target descriptionC-X-C motif chemokine ligand 10
- Target synonyms10 kDa interferon gamma-induced protein; C7; crg-2; C-X-C motif chemokine 10; gamma IP10; gIP-10; IFI10; INP10; interferon-inducible cytokine IP-10; IP-10; mob-1; protein 10 from interferon (gamma)-induced cell line; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member 10; small-inducible cytokine B10
- HostRabbit
- IsotypeIgG
- Protein IDP02778
- Protein NameC-X-C motif chemokine 10
- Scientific DescriptionThis chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.
- ReactivityHuman
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203