Anti-demetalated SOD1 [D3-1], Mouse IgG2a, Fc Silent(tm), kappa

Absolute Antibody

Anti-demetalated SOD1 [D3-1], Mouse IgG2a, Fc Silent(tm), kappa

9

This antibody recognized SOD1A4V, SOD1H46R, SOD1G85R, SOD1G93A, and SOD1I112M, but not SOD1WT. Further the antibody did not recognize SOD1 in patients with sporadic ALS or other neurodegenerative diseases.

The original antibody was used for immunohistochemistry on spinal cord sections from patients with FALS. This antibody was used in vivo on transgenic rats with SOD1H46R mutation. The treatment improved phenotypes and extended the lifespan of the rats. This antibody was used for an ELISA on recombinant protein SOD1G93A (Minamiyama et al., 2023; PMID:36874245).

ELISA, ImmunoHistoChemistry, Other Application

Research Use Only

Monoclonal

D3-1

Mouse

IgG2a

This is a reformatted mouse IgG2a Fc Silent™ antibody, based on the original mouse IgG2a format, created for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203