![anti-Detyrosinated alpha-Tubulin (human), Rabbit Monoclonal (RM444) anti-Detyrosinated alpha-Tubulin (human), Rabbit Monoclonal (RM444)](https://adipogen.com/pub/media/catalog/product/r/e/rev-31-1335-00-rm444_fig2_if_dtyr-tubulin.png)
anti-Detyrosinated alpha-Tubulin (human), Rabbit Monoclonal (RM444)
![Research Use Only](static/images/certificates/ruo.jpg)
REV-31-1335-00
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetTUBA1A
Overview
- SupplierRevMAb Biosciences
- Product Nameanti-Detyrosinated alpha-Tubulin (human), Rabbit Monoclonal (RM444)
- Delivery Days Customer5
- Antibody SpecificityThis antibody reacts to detyrosinated human alpha-Tubulin. It has no cross reactivity to non-detyrosinated alpha-Tubulin.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDRM444
- Gene ID7846
- Target nameTUBA1A
- Target descriptiontubulin alpha 1a
- Target synonymsB-ALPHA-1; hum-a-tub1; hum-a-tub2; LIS3; TUBA3; tubulin alpha-1A chain; tubulin alpha-3 chain; tubulin B-alpha-1; tubulin, alpha, brain-specific
- HostRabbit
- IsotypeIgG
- Scientific DescriptionMicrotubules are key elements of the eukaryotic cytoskeleton that dynamically assemble from heterodimers of alpha- and beta-tubulin. Two different mechanisms can generate microtubule diversity: the expression of different alpha- and beta-tubulin genes, referred to as tubulin isotypes, and the generation of posttranslational modifications (PTMs) on alpha- and beta-tubulin. Tubulin PTMs include the well-known acetylation or phosphorylation, and others that have so far mostly been found on tubulin, detyrosination/tyrosination, polyglutamylation and polyglycylation. These PTMs might have evolved to specifically regulate tubulin and microtubule functions. Detyrosination is a form of posttranslational modification that occurs on alpha-tubulin. It consists of the removal of the C-terminal tyrosine to expose a glutamate at the newly formed C-terminus. Tubulin polymers, called microtubules, that contain detyrosinated alpha-tubulin are usually referred to as Glu-microtubules while unmodified polymers are called Tyr-microtubules. - Recombinant Antibody. This antibody reacts to detyrosinated human alpha-Tubulin. It has no cross reactivity to non-detyrosinated alpha-Tubulin. Apllication: WB. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Microtubules are key elements of the eukaryotic cytoskeleton that dynamically assemble from heterodimers of alpha- and beta-tubulin. Two different mechanisms can generate microtubule diversity: the expression of different alpha- and beta-tubulin genes, referred to as tubulin isotypes, and the generation of posttranslational modifications (PTMs) on alpha- and beta-tubulin. Tubulin PTMs include the well-known acetylation or phosphorylation, and others that have so far mostly been found on tubulin, detyrosination/tyrosination, polyglutamylation and polyglycylation. These PTMs might have evolved to specifically regulate tubulin and microtubule functions. Detyrosination is a form of posttranslational modification that occurs on alpha-tubulin. It consists of the removal of the C-terminal tyrosine to expose a glutamate at the newly formed C-terminus. Tubulin polymers, called microtubules, that contain detyrosinated alpha-tubulin are usually referred to as Glu-microtubules while unmodified polymers are called Tyr-microtubules.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203